The rates of middle molecules in the blood in rats with different motor activity in alcoholic and non alcoholic exerimental hepatosis

Alcohol use disorders affect millions of individuals worldwide. The impact these facts lies in the elevated social and economic costs. Liver metabolizes 75-98 % ethanol that enters organism. If level alcohol liver cells exceeds its degradation rate, alcoholic disease develops.
 aim study was to determine peculiarities hepatotoxicity after simulation hepatosis non-alcoholic steatohepatitis high low-motor active rats.
 Material methods investigation. experiments were performed on 72 white outbred male rats. animals divided into three groups: control, non-alkoholic hepatitis (NAH), (EH). Each group subdivided – with activity (HA LA). Contents middle-mass molecules (MMM) determined blood serum.
 Results. analysis results shows levels MMM serum are increasing. Dystrophic changes appear a consequence hypoxia noted NAH EH. Both morphological biochemical more significant HA animals. degree accumulation depends severity pathology motor Less MMM238 is observed rats, which can be explained by development multi-organ pathology.
 Conclusions. During our investigations it found increasing rats nonalkoholic hepatitis. not only marker endotoxication, they also increase course pathological process, acquiring roles secondary toxins, viability all organs systems. moto simulated highly animals, compared low-active using.
 EH, pathology, particular, renal impairment. Morphological showed grade injury